Tpa Clot Buster
- Tpa Clot Buster Side Effects
- Tpa Clot Buster Dangers
- Picc Line Clot Buster Medication
- Tpa Clot Buster Name
This study will recruit patients who have recently had a submacular haemorrhage (bleed under the part of the retina responsible for detailed vision), as a complication of wet age-related macular degeneration (wet AMD). Wet AMD is a very common disease where abnormal blood vessels form under the retina and leak, causing a significant reduction in vision.
After the catheter is positioned within the blocked artery, tPA can be injected to dissolve the clot. Alternatively, a device can be used to suction the clot (aspiration) or trap the clot and remove it (retrieval). TPA is a protein produced by the body and has several functions. One is to activate the enzyme plasmin, which breaks down clots. But Yepes' team has discovered that the protein has additional functions. Ever since its introduction in the 1990s, the 'clot-busting' drug tPA has been considered a 'double-edged sword' for people experiencing a stroke. Clot-busting drugs and other advanced treatments Comprehensive stroke centers, such as PeaceHealth Southwest Medical Center, offer advanced stroke treatments designed to restore blood flow to the brain, reverse the effects of a stroke, and prevent any permanent brain damage.Advanced stroke treatments available at PeaceHealth Southwest include:tPA (tissue plasminogen activator)tPA is a clot. Thrombolytics break up clots by activating fibrinolysis and converting plasminogen to plasmin which lyses the clot. This allows blood and oxygen to reperfuse the area, limiting tissue damage. This study investigates the use of two drugs: tissue plasminogen activator (tPA), a 'clot-buster' drug used to treat stroke, which is designed to dissolve the clot over the central retina (macula); and perfluoropropane (C3F8), a gas commonly used in retinal surgery, which is designed to displace the clot away from the macula.
The study will investigate treatment of the bleed with various combinations of the two drugs: tissue plasminogen activator (tPA) - designed to dissolve the blood clot; and perfluoropropane (C3F8) - designed to shift the blood clot away from the central part of the retina (the macula). tPA is a commonly used 'clot-buster' drug for the treatment of stroke. C3F8 is a gas commonly used in eye surgery. Patients recruited will be divided into four groups: control group that receive none of the above drugs; one group that receives only tPA; one group that receives only C3F8; and one group that receives both.
All patients will receive the current gold standard treatment for wet AMD, ranibizumab (Lucentis®).
The aim of the study is to improve vision in a condition, which left untreated, would cause severe visual loss.
You’ve most likely heard of TPA because of its widespread usage in ischemic stroke, but did you know there are several other uses for this clot-busting drug as well? In this podcast episode, Nurse Mo talks about the five common uses for TPA and what you are going to monitor as you give this very potent (and potentially risky) medication.
Tpa Clot Buster Side Effects
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Tpa Clot Buster Dangers
Picc Line Clot Buster Medication
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